منابع مشابه
Guanidine Structure and Hypoglycemia
By a series of structural changes, Frank, Nothmann, and Wagner (1) developed synthalin, the most powerful hypoglycemic synthetic product known today. The details of their researches are not available. The increased hypoglycemic activity of agmatine over guanidine offered the first clue as to the nature of the groups which were productive of hypoglycemic activity. It may be gathered from the rec...
متن کامل[Total synthesis of marine cyclic guanidine compounds and development of novel guanidine type asymmetric organocatalysts].
Crambescidins and batzelladines, novel marine guanidine alkaloids, have unique pentacyclic and tricyclic guanidine core structures, respectively. They display a considerable array of biological activity and not surprisingly have attracted considerable synthetic interest. The first total synthesis of crambescidin 359 (7) and stereoselective total synthesis of batzelladine D (11) were accomplishe...
متن کاملCytotoxic guanidine alkaloids from Pterogyne nitens.
As part of a bioprospecting program aimed at the discovery of potential anticancer drugs, two new guanidine-type alkaloids, nitensidines D and E (1, 2), and the known pterogynine (3), pterogynidine (4), and galegine (5), were isolated from the leaves of Pterogyne nitens. The structures of 1 and 2 were established on the basis of spectroscopic data interpretation. These compounds were tested aga...
متن کاملPolycyclic Guanidine Alkaloids from Poecilosclerida Marine Sponges
Sessile marine sponges provide an abundance of unique and diversified scaffolds. In particular, marine guanidine alkaloids display a very wide range of biological applications. A large number of cyclic guanidine alkaloids, including crambines, crambescins, crambescidins, batzelladines or netamins have been isolated from Poecilosclerida marine sponges. In this review, we will explore the chemodi...
متن کامل2-(1,3-Benzothiazol-2-yl)guanidine
In the title comound, C(8)H(8)N(4)S, one of the two independent mol-ecules is essentially planar (r.m.s. deviation = 0.025 Å), while the other is slightly buckled (r.m.s. deviation = 0.131 Å) with the guanidine unit bent out of the plane of the fused-ring system by 16.8 (1)°. In the crystal, inter-molecular N-H⋯N hydrogen bonds between the two independent mol-ecules give rise to a hydrogen-bond...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2010
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.58.1555